Medicine (Baltimore). 1997 Jan;76(1):30-41. Links
Chryseobacterium meningosepticum: an emerging pathogen among immunocompromised adults. Report of 6 cases and
literature review.Bloch KC, Nadarajah R, Jacobs R.
Department of Medicine, University of California, San Francisco 94143, USA.

Chryseobacterium meningosepticum is a ubiquitous Gram-negative bacillus historically associated with meningitis in
premature neonates. We report 15 positive cultures and 6 cases of infection among immunocompromised adults at our
institution over a 10-year period and review the English-language literature on C. meningosepticum. Excluding the
present series, there are 308 reports of positive cultures in the literature, of which 59% were determined to represent
true infections. Sixty-five percent of those infected were younger than 3 months of age. Meningitis was the most common
infectious syndrome among neonates, seen in 84% of cases and associated with a 57% mortality rate. Less commonly
reported infections among infants included sepsis (13%) and pneumonia (3%). Pneumonia was the most frequent
infection among the postneonatal group, accounting for 40% of cases, followed by sepsis (24%), meningitis (18%),
endocarditis (3%), cellulitis (3%), abdominal infections (3%), eye infections (3%), and single case reports of sinusitis,
bronchitis, and epididymitis. The 6 cases in our series were all adults, with a mean age of 58.7 years. Sites of C.
meningosepticum infection were limited to the lungs, bloodstream, and biliary tree. Infection in our series was associated
with prolonged hospitalization, prior exposure to multiple antibiotics, and host immunocompromise, particularly
neutropenia. C. meningosepticum is resistant to multiple antibiotics, and disk dilution is notoriously unreliable for
antibiotic sensitivity testing. Sensitivity testing on the 15 isolates from our institution revealed the most efficacious
antibiotics to be minocycline (100% sensitive), rifampin (93%), trimethoprim-sulfamethoxazole (67%), and ciprofloxacin
(53%). In contrast to reports in the literature, the isolates in our series displayed widespread resistance to vancomycin
(100% resistant or intermediately sensitive), erythromycin (100%), and clindamycin (86%). These findings have
important implications for the clinician when choosing empiric antibiotic regimens for patients with risk factors for C.
meningosepticum infection.

J Microbiol Immunol Infect. 2008 Apr;41(2):137-44. Links
Chryseobacterium meningosepticum infection: antibiotic susceptibility and risk factors for mortality.Hung PP, Lin YH, Lin
CF, Liu MF, Shi ZY.
Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung,

BACKGROUND AND PURPOSE: A limited range of antibiotic classes are available for treatment of Chryseobacterium
meningosepticum infections. Although the role of C. meningosepticum in newborn infections and immunocompromised
hosts has been recognized, clinical data detailing these infections remain limited. This retrospective study investigated
the risk factors for mortality in patients with C. meningosepticum infections and the antibiotic susceptibility of clinical
isolates. METHODS: Information on demographic characteristics, clinical parameters, antibiotic treatment, and outcomes
was collected. Statistical significance of potential prognostic parameters was analyzed by Fisher's exact test. The
antimicrobial susceptibility of 19 isolates to seven antibiotics was determined, and susceptibility results were presented
as minimal inhibitory concentration (MIC) range, MIC at which 50% of isolates were inhibited (MIC(50)), and MIC at which
90% of isolates were inhibited (MIC(90)). RESULTS: Hypoalbuminemia (<2.5 g/dL) [p=0.02] and increased pulse rate
(p=0.008) at the onset of infection, and presence of an indwelling central venous line (p=0.04) were associated with
poor outcomes. Use of appropriate antibiotics was not significantly associated with the clinical outcome (p=0.21). MIC
values of levofloxacin (MIC(50)/(90), 0.12/2 microg/mL) were lower than those of ciprofloxacin (0.5/4 microg/mL).
CONCLUSION: Hypoalbuminemia, increased pulse rate at the onset of infection and presence of central venous line
infection were associated with a poor outcome in patients with C. meningosepticum.

PMID: 18473101 [PubMed - indexed for MEDLINE]

Related articles
Chryseobacterium meningosepticum infections in a dialysis unit. Ceylon Med J. 2004 Jun; 49(2):57-60.
[Ceylon Med J. 2004]
Antimicrobial susceptibility and epidemiology of a worldwide collection of Chryseobacterium spp: report from the
SENTRY Antimicrobial Surveillance Program (1997-2001). J Clin Microbiol. 2004 Jan; 42(1):445-8.
[J Clin Microbiol. 2004]
Tigecycline and colistin susceptibility of Chryseobacterium meningosepticum isolated from blood in Taiwan. Int J
Antimicrob Agents. 2009 Jul; 34(1):100-1. Epub 2009 Mar 3.
[Int J Antimicrob Agents. 2009]
ReviewChryseobacterium meningosepticum: an emerging pathogen among immunocompromised adults. Report of 6
cases and literature review. Medicine (Baltimore). 1997 Jan; 76(1):30-41.
[Medicine (Baltimore). 1997]
ReviewAn adult case of Chryseobacterium meningosepticum meningitis. Jpn J Infect Dis. 2004 Oct; 57(5):214-5.
[Jpn J Infect Dis. 2004]
» See reviews... | » See all...