J Clin Microbiol. 1994 November; 32(11): 2686–2691.  PMCID: PMC264143

Copyright notice
Primary identification of Aureobacterium spp. isolated from clinical specimens as "Corynebacterium aquaticum".
G Funke, A von Graevenitz, and N Weiss
Department of Medical Microbiology, University of Zürich, Switzerland.
This article has been cited by other articles in PMC.
Over a 6-year period 11 yellow-pigmented gram-positive rods (GPRs) with an oxidative carbohydrate metabolism were
isolated from clinical specimens or were received as reference cultures and tentatively identified as "Corynebacterium
aquaticum" according to the guide of Hollis and Weaver for the differentiation of GPRs (D. G. Hollis and R. E. Weaver,
Gram-Positive Organisms: a Guide to Identification, 1981). Because these isolates seemed to be rather heterogeneous,
comparative analyses with the type strain of "C. aquaticum" as well as six type strains of species belonging to the genus
Aureobacterium were performed by biochemical and chemotaxonomic methods. Only four clinical strains were found to
be "C. aquaticum," whereas seven strains were found to belong to the genus Aureobacterium. Discriminative
phenotypic reactions between "C. aquaticum" and Aureobacterium spp. included hydrolysis of gelatin and casein (both
reactions negative for "C. aquaticum" strains but positive for most Aureobacterium strains). Moreover, peptidoglycan
analysis provided a reliable means of differentiating yellow-pigmented GPRs at the genus level (diaminobutyric acid as
the interpeptide bridge in "C. aquaticum" and glycine-ornithine as the interpeptide bridge in Aureobacterium spp.).
Antimicrobial susceptibility testing revealed that vancomycin showed an intermediate MIC for three of the four clinical "C.
aquaticum" isolates, whereas all Aureobacterium strains were susceptible to vancomycin. To our knowledge, this is the
first report outlining the isolation of Aureobacterium spp. from clinical specimens. However, Aureobacterium isolates
could not be identified to the species level by the tests used in the study.

J Clin Microbiol. 1996 June; 34(6): 1540–1541.  PMCID: PMC229057

Copyright notice
Case of fatal systemic infection with an Aureobacterium sp.: identification of isolate by 16S rRNA gene analysis.
P Saweljew, J Kunkel, A Feddersen, M Baumert, J Baehr, W Ludwig, S Bhakdi, and M Husmann
Institute of Medical Microbiology and Hygiene, University of Mainz, Germany.
This article has been cited by other articles in PMC.
The case of a 75-year-old man who succumbed to a disseminated infection most likely caused by a species of the
genus Aureobacterium is reported. Identification of the isolate was achieved by comparative 16S rRNA gene analysis.
Aureobacteria are commonly found in the environment. However, only recently have they been recognized as a cause
of infections including septicemia and soft tissue infections. To our knowledge, this is the first documentation of a fatal
infection caused by an Aureobacterium sp.

JOURNAL OF CLINICAL MICROBIOLOGY, Aug. 1996, p. 1992–1994 Vol. 34, No. 8
Copyright q 1996, American Society for Microbiology
Vancomycin-Resistant Aureobacterium Species Cellulitis and
Bacteremia in a Patient with Acute Myelogenous Leukemia
Departments of Pathology and Laboratory Medicine1 and Medicine,2 Emory University School of Medicine, Atlanta,
Georgia, and Department of Medical Microbiology, University of Zu¨rich, CH-8028 Zu¨rich, Switzerland3
Received 8 February 1996/Returned for modification 25 March 1996/Accepted 14 May 1996
A 39-year-old male with acute myelogenous leukemia and concomitant porphyria cutanea tarda was admitted
to the hospital for consolidation chemotherapy of his leukemia. During his hospitalization, he developed
cellulitis of the left hand and persistent bacteremia with a yellow-pigmented, nonfermenting coryneform
bacterium that was identified as Aureobacterium sp. The portal of entry for the Aureobacterium infection was
probably through the skin lesions due to porphyria cutanea tarda. The infection developed while the patient
was receiving vancomycin prophylaxis, and the vancomycin MIC for the isolate was 32 mg/ml.
J Med Microbiol 48 (1999), 965-970; DOI: 10.1099/00222615-48-10-965

Aureobacterium masquerading as ‘Corynebacterium aquaticum’ infection: case report and review of the literature
David I. Grove1, Vanik Der-Haroutian1 and Rodney M. Ratcliff*
1Department of Clinical Microbiology and Infectious Diseases, Queen Elizabeth Hospital and Institute of Medical and
Veterinary Science, Woodville

*Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia

Received October 11, 1998 Revision received January 7, 1999.
A gram-positive bacillus was isolated repeatedly from blood taken through the lumina of a central venous catheter of a
patient with multiple myeloma who developed febrile neutropenia following chemotherapy. The bacterium was identified
by the API CORYNE system as ‘Corynebacterium aquaticum’. Gene analysis targeting the 16S rRNA indicated that the
organism had a 99.5% identity with Aureobacterium liquefaciens although there were two phenotypic characteristics at
variance with the description of this species. Problems remain with the routine identification of ‘C. aquaticum’ and
Aureobacterium species. The few clinical reports on patients infected with ‘C aquaticum’ and A. liquefaciens indicate
that these are rare infections often associated with immunocom-promise.