Symptoms usually begin 1 to 12 weeks after infection. The first symptom is a painless, red nodule that slowly enlarges
into a round, raised lump. The lump then breaks down to form a sore near the site of the initial infection:

Penis, scrotum, groin, and thighs in men
Vulva, vagina, and surrounding skin in women
Face in both sexes
Anus and buttocks in people who have anal intercourse

Sores may spread to other areas. They heal slowly and cause scarring. Occasionally, the infection spreads through the
bloodstream to the bones, joints, or liver.

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